Acetic Acid Hydrazide Synthesis Essay

Organic Synthesis Laboratory, School of Chemistry, Sambalpur University, Jyoti Vihar, Burla 768019, Orissa, India

State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, 116024, P.R. China

§ School of Applied Sciences (Chemistry), KIIT University, Bhubaneswar 751024, India

National Institute of Science & Technology, Palur Hill, Berhampur 761068, Orissa, India


Poulomi Majumdar obtained her M.Sc. degree from Ranvenshaw College, Utkal University, India, in 2006, and M.Phil. degree from School of Chemistry, Sambalpur University, India, with specialization in Organic Synthesis in 2007. As a Project Fellow, UGC Research Project, she received her Ph.D. degree under the supervision of Dr. A.K. Behera from the same University in July, 2012, in the area of Organic Synthesis. Currently, she is working as Postdoctoral fellow in the Molecular photophysics and photochemistry group of Prof. Jianzhang Zhao, Dalian University of Technology, China. Her scientific research interest includes synthesis of heterocycles, spiroheterocycles, fluorescent molecular probes and phosphorescent transition metal complexes including their study on photophysical properties with steady-state and timeresolved spectroscopy followed by DFT calculations.


Anita Pati was born in Sambalpur, Odisha, India, in 1977. She obtained her M.Sc. degree in 2002, and M.Phil. degree in 2003, from Sambalpur University, India. During her Ph.D. she worked with Prof. R. K. Behera in the area of organic synthesis and after receiving her Ph.D. degree from Sambalpur University in August 2010, she joined the group of Dr. Dillip Kumar Chand and Dr. Santosh J. Gharpure, Indian Institute of Technology Madras, Chennai, India, to pursue her postdoctoral research work in the area of supramolecular Chemistry. After the successful completion of her postdoctoral research training, presently she is working as an Assistant Professor in the School of Applied Sciences (Chemistry), KIIT University, Bhubaneswar. Her research interest includes organic synthesis, new synthetic methods and supramolecular chemistry.


Manabendra Patra was born in Cuttack, India. He received his M.Sc. (1991) and M.Phil. (1993) degrees from the PG Department of Chemistry, Sambalpur University, India. He studied micellar chemistry during his M.Phil. work. He obtained his Ph.D. degree on polymer kinetics under the guidance of Professor B. K. Sinha from Sambalpur University in 1999. In the same year he joined the group of Professor Rajani Kanta Behera as a Research Associate working on organic synthesis. At present, he is an Assistant Professor at the National Institute of Science and Technology, Berhampur, Orissa. His research interest is in on surface chemistry and organic synthesis.


Rajani K. Behera was born in 1952 in Kalahandi District of Odisha, India. He received his M.Sc. degree in 1974 and Ph.D. degree in 1980 from Sambalpur University. After working at Government College, he became a Lecturer at Sambalpur University and subsequently became a Reader in 1991 and Professor in 1999. He worked with Professor G. R. Newkome at the University of South Florida on the synthesis of dendrimers from 1988 to 1991. He has one patent in the United States and another in Canada to his credit. His research interests include synthesis of heterocycles, macromolecules, and dendrimers.


Ajaya Kumar Behera was born in Nayagarh District of Odisha, India, in 1962. He received his M.Sc. degree from Utkal University in 1984 and M.Phil. and Ph.D. degrees from Berhampur University in 1990 and 1996, respectively. After working for a few years at Government College, he joined the PG Department of Chemistry, Sambalpur University, in 1997 as Senior Lecturer and became Reader in 2003. His research interest includes synthesis of pharamacologically active heterocycles, spiroheterocycles, and natural products.


(7-Hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid hydrazide (2) was prepared from (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid ethyl ester (1) and 100% hydrazine hydrate. Compound 2, is the key intermediate for the synthesis of several series of new compounds such as Schiff’s bases 3a-l, formic acid N'-[2-(7-hydroxy-2-oxo-2H- chromen-4-yl)acetyl] hydrazide (4), acetic acid N'-[2-(7-hydroxy-2-oxo-2H-chromen-4- yl)-acetyl] hydrazide (5), (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid N'-[2-(4- hydroxy-2-oxo-2H-chromen-3-yl)-2-oxoethyl] hydrazide (6), 4-phenyl-1-(7-hydroxy-2- oxo-2H-chromen- 4-acetyl) thiosemicarbazide (7), ethyl 3-{2-[2-(7-hydroxy-2-oxo-2H- chromen-4-yl)-acetyl]hydrazono}butanoate (8), (7-hydroxy-2-oxo-2H-chromen-4-yl)- acetic acid N'-[(4-trifluoromethylphenylimino)methyl] hydrazide (9) and (7-hydroxy-2- oxo-2H-chromen-4-yl)acetic acid N'-[(2,3,4-trifluorophenylimino)-methyl] hydrazide (10). Cyclo- condensation of compound 2 with pentane-2,4-dione gave 4-[2-(3,5- dimethyl-1H-pyrazol-1-yl)-2-oxoethyl]-7-hydroxy-2H-chromen-2-one (11), while with carbon disulfide it afforded 7-hydroxy-4-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-2H- chromen-2-one (12) and with potassium isothiocyanate it gave 7-hydroxy-4-[(5- mercapto-4H-1,2,4-triazol-3-yl)methyl]-2H-chromen-2-one (14). Compound 7 was cyclized to afford 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)-N ́-(4-oxo-2-phenylimino- thiazolidin-3-yl) acetamide (15). View Full-Text

Keywords: Coumarin hydrazide; Schiff’s bases; thiosemicarbazide; oxadiazole; triazole; thiazolidine; antimicrobial activity.Coumarin hydrazide; Schiff’s bases; thiosemicarbazide; oxadiazole; triazole; thiazolidine; antimicrobial activity.

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MDPI and ACS Style

Cacic, M.; Trkovnik, M.; Cacic, F.; Has-Schon, E. Synthesis and Antimicrobial Activity of Some Derivatives on the Basis (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic Acid Hydrazide. Molecules2006, 11, 134-147.

AMA Style

Cacic M, Trkovnik M, Cacic F, Has-Schon E. Synthesis and Antimicrobial Activity of Some Derivatives on the Basis (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic Acid Hydrazide. Molecules. 2006; 11(2):134-147.

Chicago/Turabian Style

Cacic, Milan; Trkovnik, Mladen; Cacic, Frane; Has-Schon, Elizabeth. 2006. "Synthesis and Antimicrobial Activity of Some Derivatives on the Basis (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic Acid Hydrazide." Molecules 11, no. 2: 134-147.

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